Endocrine Abstracts

The aim: To test cytotoxic effects of immune factors of patients with chronic diabetic foot ulcers on keratinocytes and fibroblasts in a 3D skin culture system.Materials and methods: In this study a multilayer 3D human skin model comprising of keratinocytes, fibroblasts and dendritic cells in an agarose-fibronectin gel was used. 20% serum of 13 patients with chronic noninfected diabetic foot ulcers, 13 diabetic type 2 patients and 13 healthy people and l...

Objective: To study the effectiveness of therapy and the role of adherence to treatment in patients with DM and AH.Methods: A 75 patients studied with Moriski-Green test. Psycho-correctional work has been carried out with 37 people (Group 1) in order to increase motivation for treatment, and the work has not been carried out with 38 people (Group 2). The treatment effect has been evaluated after 3 months according the results of sBP and dBP dynamics and ...

The concept of a subclinical form of diabetic peripheral neuropathy (DPN) is well established. Although there has been considerable research of peripheral neuropathy in type 1 diabetes, still there is controversy regarding the pattern of nerve involvement in diabetic neuropathy. Detection of the pattern of nerve involvement can help to establish a protocol for screening of DPN in its subclinical stage.Aim: The aim of this study was to describe the patter...

Introduction: Besides medullary thyroid carcinoma and other endocrinopathies, people with MEN 2B have intestinal ganglioneuromatosis. A recent MEN2B cohort study reported high rates of gastrointestinal (GI) symptoms: we hypothesized these might have a major impact on patients’ daily lives.Methods: An online survey was conducted among patients from Association for Multiple Endocrine Neoplasia Disorders (AMEND). This incorporated relevant elements fro...

Diabetes mellitus (DM) is a metabolic disease, which is accompanied by systemic damage to organs, including the central nervous system. Clinically, these changes are associated with cognitive impairment, the pathogenesis of which is also largely heterogeneous.Objective: To evaluate the role of tau-protein in the diagnosis of cognitive impairment in patients with type 1 and type 2 diabetes.Materials and methods: The study was tested...

Background: Insulin resistance and dyslipidemia inobese subjectsare important for predicting future cardiovascular risk. Purpose of the study was to analyze the lipid profile of obese children depending on gender and insulin resistance status.Subjects and methods: 247 overweight and obese children (160 boys and 87 girls) aged 2 to 18 y.o. were examined in the pediatric endocrinology department. Lipids assessment included measurement of total cholest...

Purpose of the studyEvaluation of cerebral microcirculation using contrast and non-contrast magnetic resonance perfusion in patients with type 1 diabetes and cognitive dysfunction.Material and methodsThe study complied with generally accepted ethical rules. The study included 45 patients with type 1 diabetes mellitus with cognitive dysfunction and 20 patients without. All patients were continuously monitored ...

Introduction: Post-prandial hyperglycaemia seems to play a pivotal role in the pathogenesis of cardiovascular complications of diabetes mellitus, as it leads to oxidative stress which in turn causes reduced NO bioavailability that produce endothelial activation.Aim: Aim of the study was to assure that the administration of N-acetylcysteine (NAC), thiolic antioxidant, is able to decrease oxidation status and endothelial activation after a high-gluc...

The main aims of treatment of acromegaly are reversing symptoms and signs, removing the tumour, preventing disease recurrence, and improving survival. Increased mortality associated with acromegaly can be diminished if treatment is successful in reducing GH <2–2.5 ng/ml. We carried out a prospective study to assess whether recent advances in surgical technique (namely the endoscopic approach in a specialised centre encompassing specialist pituitary surgeons working in...

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...